Sulfonylation [SO3/H2SO4]

Sulfonylation [SO₃/H₂SO₄] Definition:

Treatment of an aromatic molecule such as benzene with sulfur trioxide and strong acid leads to tát the formation of sulfonic acid in the reaction of electrophilic aromatic substitution.

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Sulfonylation [SO₃/H₂SO₄] Explained:

Concentrated sulfuric acid does not sulfonate benzene at room temperature. However, when benzene is treated with fuming sulfuric acid, a sulfonylation reaction occurs and benzene-sulfonic acid is obtained. Fuming sulfuric acid is a mixture of sulfuric acid, H₂SO₄and sulfur trioxide, SO₃which is very powerful electrophile. Aromatic sulfonylation is a reverse process and if benzene-sulfonic acid is heated with dilute aqueous sulfuric acid, the starting benzene is obtained.

Mechanism of Aromatic Sulfonylation

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In the first step, the benzene functions as a nucleophile forming an intermediate which is deprotonated in the next step, restoring aromaticity. And the last step is protonation of the sulfonic group and obtaining the final product.